The Lord Mayor will place a wreath in honour of the author, who was born in Landport in 1812.
The museum will be open all day with hourly readings from the author’s works.
Cllr Pitt, Cabinet Member for Culture and City Development at Portsmouth City Council said: “This is an important anniversary to mark and chance to celebrate the life and work of one of the world’s most acclaimed authors who was born in the city.”
For further information and opening times please check the Charles Dickens Birthplace website at charlesdickensbirthplace.co.uk or Tel: 02392827261